SUO 2018: Influence of dietary consumption on human metabolism and cancer risk - UroToday

Phoenix, Arizona (UroToday.com) At the meeting titled "The Interval of Fasting, Metabolism, and Cancer Risk," Dr. Marinac on the...

Phoenix, Arizona (UroToday.com) At the meeting titled "The Interval of Fasting, Metabolism, and Cancer Risk," Dr. Marinac on the clinical effects of food intake on the metabolic health and risks of cancer patients. The principle is that fasting is restricted (TRF for its acronym in English), which is called nocturnal fasting, for more cancers that are related to obesity, that may be relevant and relevant (see below) to connect more with others like prostate cancer.

Can consumption times impact on metabolic and cancer endpoints in humans? The distribution of nocturnal fasting (in hours) of women in the NHANES study is listed below:

Therefore, some patients are already fasting at night. Prolonged nocturnal fasting is associated with better glycemic control and lower CRP levels.

He then discussed the study "Healthy Living and Feeding for Women", a controlled controlled intervention trial with 3,088 breast cancer survivors. Patients were followed longitudinally and measurements were repeated at the beginning of the study for 1 and 4 years. The clinical endpoints studied were breast cancer events (7.3 years follow-up) and mortality (cancer-specific and general).

Lentings for the night were estimated using diets with timestamps.
The recurrence of breast cancer was significantly lower in patients with nocturnal fasting> = 13 hours compared to <13 hours
HR for specific survival of breast cancer (nocturnal fasting> = 13 hours vs. <13 hours): HR 1.21, p = 0.19
There was also no difference in overall mortality

Finally, they recently completed a study examining the possibility of 12-hour fasting. They prospectively examined 20 postmenopausal obese women (50% of Latinas). Then they finished the following intervention:

After a month, they noticed the following results:

Although this is not planned (and this is not explained to the patient as a potential benefit), they found a weight loss of 1 kg in one month regardless of the breed. The average nightly fasting time was 13-13.2 hours, based on 10.6-10.8 hours. There was no difference depending on the breed.

More important:

90% said fasting was easy.
90% said they could fast for more than 12 hours.
70% said they prefer SMS over phone calls.
90% found the fast something pleasant

Based on these studies, she concludes that prolonged nocturnal fasting is achievable without any indication of patient impairment. It can also improve the prognosis of cancer.

Takeaway Statement: Prolonged fasting at night may be a strategy to reduce cancer risk, as well as excessive morbidity and mortality in cancer survivors.

Presented by: Catherine Marinac, PhD, Dana-Farber Cancer Institute, Boston

Thenappan Chandrasekar, MD, Clinical Instructor, Thomas Jefferson University, twitter: @tchandra_uromd at the 19th Annual Urological Oncology Society (OUA), 28-30 November 2018 - Phoenix, Arizona