SUO 2018: Influence of Food Intake on Metabolic Health and Cancer Risk in Humans - UroToday

Phoenix, Arizona (UroToday.com) At the meeting titled "The Interval of Fasting, Metabolism, and Cancer Risk," Dr. Marinac the cl...

Phoenix, Arizona (UroToday.com) At the meeting titled "The Interval of Fasting, Metabolism, and Cancer Risk," Dr. Marinac the clinical effects of food intake on health Metabolism and cancer risk in the body. People. The principle is that fasting (TRF for the acronym in English), which refers to nocturnal fasting, may be associated with the various types of cancers associated with obesity (see below) more freely associated with others, such as prostate cancer ,

Can a meal affect human metabolism and cancer endpoints? The distribution of nocturnal fasting (in hours) of women in the NHANES study is listed below:

As a result, some patients are already fasting at night. A longer nocturnal fast is associated with better glycemic control and lower CRP levels.

He went on to discuss the Healthy Life and Feeding Study for Women, which was a randomized controlled intervention trial with 3,088 breast cancer survivors. Patients were followed longitudinally and the measurements repeated at the beginning of the study, 1 and 4 years. The evaluated clinical endpoints were breast cancer events (7.3 years follow-up) and mortality (cancer-specific and general).

• Overnight Lenten times were estimated based on nutritional reminders with timestamps.
• The recurrence of breast cancer was significantly lower in patients with nocturnal fasting> = 13 hours compared to <13 hours
• HR for specific survival of breast cancer (nocturnal fasting> = 13 hours vs. <13 hours): HR 1.21, p = 0.19
• There was also no difference in overall mortality

Most recently, they completed a study analyzing the possibility of 12-hour night fattening. They prospectively evaluated 20 overweight postmenopausal women (50% of Latin Americans). Then they finished the following procedure:

After 1 month, they found the following results:

Although it is not expected (and this is not explained as a potential benefit for the patients), they found a 1 kg weight loss in one month, regardless of race. The average nocturnal fast was 13-13.2 hours, based on 10.6-10.8 hours. There was no difference depending on the breed.

More important:

• 90% said fasting was easy.
• 90% said they could fast for more than 12 hours.
• 70% say that they prefer SMS over phone calls.
• 90% found the fast something pleasant

Based on these studies, it concluded that overnight can be rapidly extended without any signs of patient injury. It can also improve the prognosis of cancer.

Takeaway statement: Prolonged nocturnal fasting may be a strategy to reduce cancer risk, as well as excessive morbidity and mortality in cancer survivors.

Presented by: Catherine Marinac, PhD, Dana-Farber Cancer Institute, Boston

Written by Thenappan Chandrasekar, MD, clinical instructor, Thomas Jefferson University, twitter: @tchandra_uromd at the 19th Annual Society of Urological Oncology (SUO) 28-30 November 2018 - Phoenix, Arizona